Defenders of Wildlife today released a first-of-its-kind report that maps out where the five drivers of the global biodiversity crisis — habitat loss, pollution, climate change, invasive species and overexploitation — may have the greatest impact in the contiguous United States. This work is the first to analyze all five threats together at the national scale and the first to find that climate change, rather than habitat loss, endangers the greatest number of the nation’s most imperiled species.